Table 1. Selected MMP-9 Single Nucleotide Polymorphisms Investigated.

Heterozygosity
Name	rs# ID	SNP	Mutation	October 2010	January 2012	Domain	Protein Secretion	Total Enz. Activity	Promoter Activity
A20V	rs1805088	C>T	Ala>Val	0.057	0.051	Sig.pept.	Down
N38S	rs41427445	A>G	Asn>Ser	0.133	0.023	Propep.N-glyco.	Down	Down
E82K	rs1805089	G>A	Glu>Lys	N.D.	0.000	Propep.	Down	Down
D165N*	rs8125581	G>A	Asp>Asn	N.D.	0.002	Catalytic	Down	Down
L187F	rs55789927	C>T	Leu>Phe	N.D.	0.001	Catalytic		Down
T258I	rs41529445	C>T	Thr>IIe	0.039	0.003	Catalytic
R279Q	rs17576	G>A	Arg>GIn	ND	0.440	Catalytic		Up
P574R	rs2250889	C>G	Pro>Arg	0.293	0.213	Hemopexin	Down
R668Q	rs17577	G>A	Arg>Gln	0.287	0.280	Hemopexin		Up
p-1562	rs3918242	C>T		0.288	0.290	Promoter			Up
p-1702	rs3918241	T>A		0.258	0.249	Promoter			Down
p-2024	rs6104421	C>T		0.146	0.151	Promoter
p-2118	rs3918240	C>T		0.470	0.463	Promoter			Up
p-2502*	rs8113877	G>T		0.423	0.426	Promoter			Down

MMP-9 indicates matrix metalloproteinase-9; SNP, single nucleotide polymorphism; Total enz. activity, total enzymatic activity; Sig. pept, signal peptide; Propep, propeptide; N-glyco, N-linked glycosylation; and ND, no data.

The common nomenclature used in our study denoting the amino acids changed for the exon SNPs and the location of the SNPs with respect to the start ATG for the promoter SNPs.

^*Indicates the 2 SNPs that were used in the final logistic-regression model. The SNP heterozygosity column lists the numbers available through NCBI at the time of initiation of this study (2010) and the numbers listed at the most recent access (2012). Domain lists the functional domain of the gene where the SNPs are located. Protein secretion, total nz. activity, and promoter activity, lists the functional consequences of the SNPs.