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. Author manuscript; available in PMC: 2013 Jun 3.
Published in final edited form as: Brain Res. 2012 Mar 6;1452:1–9. doi: 10.1016/j.brainres.2012.02.070

Fig. 2.

Fig. 2

Sigma1R co-expression accelerates Kv1.3 inactivation kinetics. A. Current decay of Kv1.3 alone and co-expressed with Sigma1R were fitted with a double exponential function (dashed lines). B. A double exponential fit to the current decay showed a voltage-independent fast (A1*exp(−t/tau1)) and a voltage-dependent slow components (A2*exp(−t/tau2)) of inactivation time constants. Both time constants were smaller in the co-injected oocytes (open circles) compared to those only injected with Kv1.3 cRNA (closed circles). The fast component demonstrated significant difference at all voltages (*p < 0.05). C. The ratio of the amplitudes of slow to fast decaying components (A2/A1 ratio) decreased with Sigma1R co-expression but remained independent of voltage for both groups.