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. Author manuscript; available in PMC: 2013 Jun 3.
Published in final edited form as: NMR Biomed. 2012 Mar 1;25(10):1177–1186. doi: 10.1002/nbm.2787

FIGURE 3.

FIGURE 3

Section of the forebrain NMR spectrum from a non-tumor bearing NOD/SCID mouse infused with [1,2-13C2]-glucose. Spin-coupled 13C multiplets in metabolites exchanging with Krebs cycle intermediates (i.e., glutamate, glutamine, GABA and aspartate) is observed in the 13C spectrum as a consequence of glucose oxidation in the brain. Of note, the labeling pattern of glutamate C4 (GLU4) and GABA C2 (GABA2) were comparable as GABA derives primarily from glutamate in normal brain. Insets display labeling patterns of lactate C3 and from aspartate C3 to glutamine C4. GLU: glutamate, GLN: glutamine, ASP: aspartate, LAC: lactate, TAU: taurine. 1: N-acetylaspartate C6, 2: GABA C3, 3: unassigned, 4: glutamine C3, 5: glutamate C3, 6: unassigned, 7: unassigned, 8: GABA C4, 9: N-acetylaspartate C3, 10: taurine C1, 11: aspartate C2, 12: N-acetylaspartate C2, 13: unassigned, 14: glutamine C2, 15: glutamate C2. S: singlet, Dxx: doublet, Q: quartet.