Table 3.

Two-way sensitivity analysis of DMOAD cost and pain relief, suspended progression, or major toxicity

				$1,000		$2,000		$3,000
	Treatment Strategy		Avg. QALE	Avg. Cost	ICER	Avg. Cost	ICER	Avg. Cost	ICER
Pain Relief	30% (base case)	Standard of Care*	14.21	$115,800		$115,800		$115,800
		SoC + DMOADs**	14.25	$118,100	$57,500	$121,600	$145,000	$125,200	$235,000
	40%	Standard of Care	14.21	$115,800		$115,800		$115,800
		SoC + DMOADs	14.28	$118,000	$31,400	$121,600	$82,900	$125,100	$132,900
	50%	Standard of Care	14.21	$115,800		$115,800		$115,800
		SoC + DMOADs	14.32	$118,000	$20,000	$121,500	$51,800	$125,100	$84,500
Suspended Progression	50% (base case)	Standard of Care	14.21	$115,800		$115,800		$115,800
		SoC + DMOADs	14.25	$118,100	$57,500	$121,600	$145,000	$125,200	$235,000
	60%	Standard of Care	14.21	$115,800		$115,800		$115,800
		SoC + DMOADs	14.26	$118,400	$52,000	$122,500	$134,000	$126,600	$216,000
	70%	Standard of Care	14.21	$115,800		$115,800		$115,800
		SoC + DMOADs	14.28	$118,600	$40,000	$123,300	$107,100	$128,000	$174,300
Major Toxicity	1%	Standard of Care	14.21	$115,800		$115,800		$115,800
		SoC + DMOADs	14.24	$118,100	$76,700	$121,700	$196,700	$125,100	$310,000
	0.5% (base case)	Standard of Care	14.21	$115,800		$115,800		$115,800
		SoC + DMOADs	14.25	$118,100	$57,500	$121,600	$145,000	$125,200	$235,000
	0.1%	Standard of Care	14.21	$115,800		$115,800		$115,800
		SoC + DMOADs	14.26	$118,000	$44,000	$121,600	$118,000	$125,300	$190,000

^*Standard of care sequence includes: conservative pain management (NSAIDs, acetaminophen, physical therapy), corticosteroid injections, primary TKR, revision TKR

^**Standard of care + DMOADs sequence includes: conservative pain management, DMOADs, corticosteroid injections, primary TKR, revision TKR

Abbreviations: DMOAD - disease modifying osteoarthritis drug; QALE - quality-adjusted life expectancy; ICER - incremental cost-effectiveness ratio; SoC – standard of care