Table 1. STAT5 activation in hematological malignancies.
| Kinase | Mutation/Translocation | Disease | References |
|---|---|---|---|
| Flt3 |
ITD (exon 11–12, 3–400 bp) TK point mutations (Asp835) |
AML AML |
31, 34–38 39 |
| JAK2 |
TEL-JAK2 V617F |
ALL, CML, MPD PV, ET, IMF |
40 41–44 |
| JAK3 |
A572V, V722I, P132T |
AMKL |
45 |
| c-Kit |
D816V ITD (exon 11–12) |
AML Pediatric AML |
46–48 49 |
| PDGFR |
TEL-PDGFR FIP1L1-PDGFRα |
CML, MPD Chronic Eosinophilic Leukemia |
50, 51 52, 53 |
| Abl |
v-ABL (p160) BCR-ABL (p210, p185) |
CML, BCL CML |
54 27, 55 |
| FGFR |
ZNF198-FGFR1 |
MPD |
56 |
| RARα | STAT5b-RARα | APL | 57, 58 |