Table 2. Genes required for thermotactic behavior.

Gene	Gene product	Mutant phenotype	Site of action (Neuron)	Reference
tax-4	cGMP dependent channel (a subunit)	athermotactic	AFD and AWC	12, 32, 65
tax-2	cGMP dependent channel (β subunit)	athermotactic	AFD and AWC
ttx-1	OTD/OTX homeodomain protein	cryophilic	AFD	64
ceh-14	LIM homeodomain protein	athermotactic	AFD	66
cmk-1	CaM kinase I/IV	abnormal	AFD	36
dac-1	SKI/SNO/DAC family	cryophilic	AFD	67
tax-6	Calcineurin A subunit	thermophilic	AFD	34
ttx-4	nPKC-epsilon/eta	thermophilic	AFD	35
dgk-3	diacylglycerol kinase	abnormal temperature memory	AFD	39
ncs-1	Neuronal calcium sensor	abnormal isothermal tracking	AIY	68
ttx-3	LIM homeodomain protein	cryophilic	AIY	56
ceh-10	homeodomain protein	abnormal	AIY	69
lin-11	LIM homeodomain protein	thermophilic	AIZ	70
unc-86	POU (transcriptional factor)	thermophilic	AIZ	11
ttx-7	Inositol monophosphatase	athermotactic	RIA	71
dgk-1	diacylglycerol kinase	cryophilic	unknown	35
odr-3	G protein a subunit	slightly thermophilic	AWC	12
eat-16	regulator of G protein signaling	slightly cryophilic	AWC	12
srtx-1	G protein coupled receptor	abnormal isothermal tracking	AWC	24
ttx-8	macoilin	athermotactic	AFD, AIY, AIZ and other neurons	59
crh-1	CREB protein	abnormal (cryophilic and athermotactic)	AFD	37
hsf-1	heat-shock transcription factor	abnormal temperature memory	whole body	26
nhr-69	estrogen receptor	abnormal temperature memory	AFD	26
eat-4	VGLUT homolog	athermotactic	AFD, AWC, RIA	45
glc-3	glutamate-gated chloride channel	slightly thermophilic	AIY	45
ins-1	insulin homolog	defective in association between temperature and food	neurons	72
age-1	PI-3-kinase homolog	partially defective in association between temperature and food	thermotactic interneurons	72
daf-16	forkhead-type transcriptional factor	partially defective in association between temperature and food	unknown (thermotactic interneurons)	72
hen-1	secretory protein	defective in association between temperature and food	unknown	73
gcy-28	receptor-like guanylate cyclase	defective in association between temperature and food	unknown	14