Table 1. Transgenerational effects of COMPASS deficiency on lifespan and gene expression.

Generation*	COMPASS-status (genotype)	Lifespan	Global H3K4me3	Transcriptome
P0	wild-type (+/+)	Normal	Normal	Normal
P0	deficient (mutant/mutant)	Extended	Down	Differential regulation of 7,820 genes
F1	Heterozygotes (mutant/+)	n.d.	n.d.	n.d.
F2	wild-type (+/+)	n.d.	n.d.	n.d.
F3	wild-type (+/+)	Extended	Normal	n.d.
F4	wild-type (+/+)	Extended	Normal	Differential regulation of 1,740 genes
F5	wild-type (+/+)	Normal	Normal	Normal

^*See reference 5 for the setup of the genetic cross schemes; n.d.: not determined.