Figure 5.
H2S upregulates Akt phosphorylation, VEGF expression, and activates the eNOS-NO pathway following TAC. (A) Representative immunoblots and densitometric analysis of (A-C) total Akt, Akt-PSer473, and Akt-PThr308, (D) VEGF (E-F) total eNOS and eNOS-PSer1177 in hearts from Sham, TAC+Vehicle, and TAC+SG-1002 at 6 weeks of TAC. (G) Nitrite and (H) cGMP levels in the hearts of the experimental groups at 6 weeks of TAC. Results are expressed as mean ± SEM.