Table 1. Function of miRNAs involved in STAT3-dependent circuits in various fields of development and disease.
Field | miRNA | Function | References |
---|---|---|---|
Embryonic development |
miR-93, miR-17-5p |
Germ layer differentiation |
18 |
miR-17, miR-20a, miR-106b |
Lung branching morphogenesis |
21 |
|
miR-124a, miR-9 |
Neural lineage differentiation |
19, 20 |
|
Immunity and infection disease |
miR-125b |
Myeloid cell proliferation |
22, 23 |
miR-17-5p, miR-20a |
Proliferation of myeloid derived suppressor cells |
24 |
|
miR-155 |
Innate antiviral immunity in HBV-infection |
27 |
|
let-7a |
Progression of hepatitis B to hepatocellular carcinoma |
23 |
|
Cancer disease |
miR-21, miR-19a/b |
Involvement in multiple myeloma |
34, 15, 36, 37 |
miR-21, miR-181b |
Involvement in colon adenocarcinoma |
38 |
|
miR-155, miR-20b |
Involvement in breast cancer |
35 |
|
miR-9, miR-17, miR-20a |
Involvement in glioma |
32 |
|
Cardiovascular system |
miR-199a |
Sarcomere protein ubiquitination and turnover sarcomere integration |
16 |
Myocardial vascular function |
16 |
||
miR-21 |
Regeneration through MSCs |
48 |
|
Pulmonary hypertension | miR-17-5p, miR-20a |
Fibrous matrix production |
50 |
miR-204 | Vascular remodeling | 52 |