Table 1. Summary of transplantation, transgenic or knock-in JAK2 V617F mouse models.
| Mouse model | References | Activation | Platelets | Hematocrit | MF |
|---|---|---|---|---|---|
| Retroviral overexpression |
Lacout et al.22 |
N/A |
Normal |
> 55% |
Yes |
| Wernig et al.23 |
Normal |
> 70% |
Yes |
||
| Zaleskas et al.24 |
Normal |
> 65% |
Yes |
||
| Transgenic JAK2 V617F mouse models |
Tiedt et al.29 |
MX1-Cre |
3,710 ± 488 |
49–62% |
Yes |
| Shide et al.25 |
Not inducible |
> 1,400 |
50% |
Yes |
|
| Xing et al.26 |
Not inducible |
2,708 ± 712 |
51% |
Yes |
|
| Knock-in JAK2 V617F mouse models | Akada et al.30 |
MX1-Cre |
~1.5-fold increase |
Up to 80% |
Mild heterozygous High homozygous |
| Mullally et al.32 |
Constitutive |
No increase |
Up to 80% |
No |
|
| Marty et al.31 |
Constitutive |
~4-fold increase |
Up to 70% |
Yes |
|
| Li et al.33 | MX1-Cre | ~1.5-fold increase | Up to 60% | No |