Table III.

Association between SNPs in HFE region and gastric adenocarcinoma, overall and according to localization and histological type. OR and 95% CI for log-additive model (per allele effect) estimated by unconditional logistic regression, adjusted for sex, age, center and date of blood collection

SNP	All gastric adenocarcinoma			Cardia (107 cases)		Non-cardia (181 cases)		Intestinal type (126 cases)		Diffuse type (128 cases)
	Cases/controls	OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value
rs4529296	363/1277	1.09 (0.91–1.29)	0.35	1.04 (0.77–1.41)	0.79	1.13 (0.90–1.43)	0.30	1.22 (0.93–1.61)	0.15	0.99 (0.75–1.31)	0.97
rs1799945a	323/1157	1.32 (1.03–1.69)	0.031	1.14 (0.71–1.82)	0.59	1.60 (1.16–2.21)	0.005	1.82 (1.27–2.62)	0.002	1.36 (0.92–1.99)	0.13
rs1800562b	365/1283	1.12 (0.75–1.67)	0.59	0.70 (0.33–1.51)	0.35	1.37 (0.81–2.32)	0.25	0.95 (0.48–1.88)	0.88	1.12 (0.59–2.10)	0.74
rs1572982	365/1282	1.09 (0.93–1.29)	0.29	1.06 (0.80–1.41)	0.70	1.07 (0.86–1.34)	0.54	1.40 (1.08–1.83)	0.012	1.11 (0.85–1.44)	0.45
rs707889	365/1277	0.96 (0.77–1.18)	0.67	0.96 (0.67–1.37)	0.81	0.97 (0.73–1.29)	0.83	0.88 (0.62–1.24)	0.46	0.85 (0.60–1.20)	0.35
rs1045537	365/1283	0.96 (0.74–1.26)	0.79	0.86 (0.53–1.38)	0.51	0.95 (0.65–1.39)	0.79	0.83 (0.52–1.32)	0.43	1.24 (0.83–1.86)	0.30
rs17596719	365/1282	0.95 (0.73–1.24)	0.71	1.24 (0.79–1.92)	0.35	0.82 (0.57–1.19)	0.29	1.08 (0.73–1.61)	0.70	0.80 (0.52–1.24)	0.31
rs6918586	365/1280	1.11 (0.94–1.32)	0.23	1.06 (0.79–1.43)	0.68	1.14 (0.91–1.44)	0.26	1.39 (1.06–1.82)	0.017	1.17 (0.89–1.54)	0.27
rs1543680	362/1282	0.93 (0.75–1.15)	0.48	0.95 (0.66–1.37)	0.80	0.96 (0.72–1.28)	0.76	0.81 (0.57–1.15)	0.23	0.82 (0.58–1.17)	0.28

^aH63D.

^bC282Y.