Table V.
Haplotype analysis of SNPs of HFE gene and risk of gastric adenocarcinoma
| Haplotypea | Frequencyb (%) | ORc | (95% CI) | P valuec |
|---|---|---|---|---|
| CGGCGGTG | 34.7 | 1.00 | (Reference) | — |
| CGGTGGTA | 14.5 | 1.00 | (0.77–1.30) | 0.99 |
| GGACGGCG | 14.3 | 1.34 | (1.04–1.73) | 0.024 |
| CGACGACG | 12.3 | 1.01 | (0.76–1.33) | 0.96 |
| CGACCGCG | 10.5 | 1.05 | (0.79–1.40) | 0.74 |
| CGACGGTG | 6.2 | 1.05 | (0.74–1.49) | 0.77 |
aEach haplotype is formed by the alleles corresponding to each of eight SNPs, including H63D (rs1799945) and seven tagSNPs of a linkage disequilibrium block in the HFE genomic region, ordered according to the localization in the gene: rs1799945, rs1800562, rs1572982, rs707889, rs1045537, rs17596719, rs6918586 and rs1543680. The first haplotype corresponds to the wild-type allele for each SNP. Marked with bold type, the alleles corresponding to the three SNPs are significantly associated with the univariate analysis: rs1799945, rs1572982 and rs6918586.
bOnly haplotypes with frequency 5% or above are presented; among haplotypes not shown, no significant associations were observed.
cORs and P values compared with the most frequent haplotype estimated by unconditional logistic regression, adjusted for sex, age and center.