Table II.
HOXB13 G84E carrier frequency in positive and negative biopsy subjects
| G84E carriers | G84E non-carriers | G84E carrier frequency | RR (95% CI)a | P | Homogeneity P b | |
|---|---|---|---|---|---|---|
| Negative biopsy subjects | 6 | 2485 | 0.24% | 1.00 | NA | |
| Positive biopsy subjects | 7 | 701 | 0.99% | 2.45 (1.48–4.07) | 0.01 | |
| Family history | ||||||
| Positive family history | 5 | 111 | 4.31% | 10.63 (5.43–20.83) | 6.0E-5 | 0.004 |
| Negative family history | 2 | 590 | 0.34% | 1.31 (0.39–4.34) | 0.65 | |
| Age at diagnosis | ||||||
| <65 y | 3 | 282 | 1.05% | 3.28 (1.29–8.31) | 0.06 | 0.91 |
| ≥65 y | 4 | 419 | 0.95% | 2.78 (1.29–5.97) | 0.04 | |
| Gleason grade | ||||||
| High grade (≥7) | 4 | 230 | 1.71% | 4.73 (2.19–25.71) | 0.01 | 0.29 |
| Low grade (<7) | 3 | 471 | 0.63% | 2.10 (0.83–5.30) | 0.16 | |
aRR was estimated for overall or subsets of positive biopsy subjects versus all negative biopsy subjects.
bHomogeneity P of Breslow–Day test was estimated for homogeneity of stratified analysis according to family history, age at diagnosis and Gleason grade, respectively.