Table 1. Known STATs and their activators.

Molecule	“Inflammatory” activators	“Anti-inflammatory” activators	Heterodimerization partners
STAT1	Type I IFN Type II IFN IL-6	IL-10 IL-27 IL-35	STAT2 (IFN) STAT3 (IL-6, -27) STAT4 (IL-35)
STAT2	Type I IFN		STAT1 (IFN)
STAT3	IL-2 IL-5 IL-6 IL-23 MCSF GCSF	IL-10 IL-27	STAT1 STAT5a/b
STAT4	IL-12 IL-23	IL-35	STAT1 (IL-35) STAT3 (IL-23)
STAT5a/5b	IL-2 -7 -15 IL-21 M-CSF GM-CSF		STAT3 (IL-2, -7, GCSF, MCSF)
STAT6	Type I IFN (B and human T cells) IL-3 IL-4 IL-13		STAT2 (IFN) (B and human T cells)