Table 1. Key cytokine pathways to STAT1, STAT3 and STAT4 functions.

	Cytokines that activate	Examples of target genes	Functional outcome	References
STAT1	IFNαβ, IFNγ, IFNλ, IL-6, IL-10, IL-21	Mx, PKR, OAS, inhibiting c-myc	Antiviral, pro-apoptotic, anti-proliferation, cytotoxic	19–24
STAT3	IL-6, IL-10, IL-21, IFNαβ, IFNγ, IFNλ	Bcl-XL, survivin, cyclin D1, activating c-myc	Pro-survival, pro-proliferation	32–35
STAT4	IL-12, IFNαβ	IFNγ, CD25	Pro-proliferation	24, 27–30