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. 2013 Jan 1;2(1):e23633. doi: 10.4161/jkst.23633

Table 1. STAT2 antagonism by viral proteins.

Virus Viral protein Mode of STAT2 antagonism Species References
Human parainfluenza virus 2 (hPIV2)
V protein
Protein degradation
Human, mouse
65
Parainfluenza virus 5 (hPIV5), previously Simian virus 5 (SV5)
V protein
STAT2 dependent STAT1 antagonism
Human, mouse STAT2 unaffected
41 and 67
Sendai virus (SeV)
C protein
Inhibit phosphorylation/activation by associating with STAT1
Rodent pathogen, Experiments on human cell lines
64
Hendra virus
V protein
Complex formation and cytoplasmic sequestration
Equine, Human
59
Nipah virus
V protein
Complex formation and cytoplasmic sequestration
Human
57 and 58
Measles virus
V protein
Complex formation and cytoplasmic sequestration, suppression of DC activation
Human
52 and 54
Respiratory syncytial virus (RSV)
NS1, NS2
Proteasomal degradation of complex
Human
61 and 63
Dengue virus (DENV)
NS5
Protein degradation, blocking phosphorylation
Human, mouse STAT2 unaffected
6972
Japanese encephalitis virus (JEV)
unknown
Blocking tyrosine phosphorylation
Human, non-human primate
83
Langat virus
NS5
Blocking tyrosine phosphorylation
non-human primate
84
Herpes simplex virus 2 (HSV2)
unknown
mRNA and protein degradation, blocking phosphorylation
Human
50
Lymphocytic choriomeningitis virus (LCMV)
unknown
Suppression of DC development via STAT1 independent STAT2 dependent IFN signaling
Mouse
52
Mouse cytomegalovirus (MCMV) M27 Downregulation of STAT2 protein Mouse 51