Table 1. Regulation of chemokine synthesis by IFN and STATs 1/2.
| Cell/animal | Stimulus/disease | IFN type involved | STAT involved | Chemokine regulated | References |
|---|---|---|---|---|---|
|
Mouse macrophages |
IFN-γ or IFN-γ/TNF |
IFN-γ |
STAT1 |
CCL2/MCP1 ↑ |
37, 45 and 128 |
| CXCL9/MIG ↑ | |||||
| CXCL10/IP10 ↑ | |||||
| CCL12/MCP5 ↑ | |||||
| IFN-γ/PamCys |
IFN-γ |
nd |
CCL2/MCP1 ↑ |
52 |
|
| LPS |
nd |
STAT1 |
CXCL10/IP10 ↑ |
45 and 129 |
|
| CCL12/MCP5 ↑ | |||||
| LPS/IFN-γ |
IFN-γ |
STAT1 |
CXCL1/KC/GROα ↓ |
45 |
|
| CXCL2/MIP2/GROβ ↓ | |||||
| CCL2/MCP1 ↓ | |||||
| CCL4/MIP1β ↓ | |||||
| TNF |
IFN-β |
STAT1 |
CCL5/RANTES ↑ |
11 |
|
| CXCL9/MIG ↑ | |||||
| CXCL10/IP10 ↑ | |||||
|
Listeria monocytogenes |
IFN-I |
nd |
CCL2/MCP1 ↑ |
42 |
|
|
Mouse splenocytes |
IFN-α |
IFN-α |
STAT1 |
CCL2/MCP1 ↓ |
46 |
| CCL5/RANTES ↓ | |||||
| CCL7/MCP3 ↓ | |||||
|
Human monocytes |
IFN-γ |
IFN-γ |
STAT1 |
Inhibition of migration in response to CCL2 |
130 |
| TNF |
IFN-β |
STAT1 |
CCL5/RANTES ↑ |
11 |
|
| CXCL9/MIG ↑ | |||||
| CXCL10/IP10 ↑ | |||||
| M1 polarization (IFN-γ/LPS) |
IFN-γ |
nd |
CCL5/RANTES ↑ |
44 and 131 |
|
| CCL15/MIP1δ ↑ | |||||
| CCL20/MIP3α ↑ | |||||
| CXCL9/MIG ↑ | |||||
| CXCL10/IP10 ↑ | |||||
|
Human monocyte-derived DC |
Sendai virus |
IFN-I |
ISGF3 |
CCL19/MIP3β ↑ |
40 |
|
Salmonella Typhimurium | |||||
|
Human PBMC |
IFN-λ |
IFN-λ |
nd |
CXCL9/MIG ↑ |
132 |
| CXCL10/IP10 ↑ | |||||
| CXCL11/I-TAC ↑ | |||||
|
Mouse primary cortical neurons |
IFN-α |
IFN-α |
STAT1 |
CXCL10/IP10 ↑ |
133 |
|
Human astrocytes |
IFN-γ/IL-1β |
IFN-γ |
nd |
CXCL11/I-TAC ↑ |
36 |
| IFN-β/IL-1β |
IFN-β |
ISGF3 (?) |
CCL5/RANTES ↑ |
32 |
|
|
Mouse microglia |
IFN-γ |
IFN-γ |
STAT1 |
CXCL9/MIG ↑ |
41 |
|
Human plasmacytoid DC (MS patient) |
IFN-β/TLR9 ligand |
IFN-β |
nd |
CCL3/MIP1α ↓ |
48 |
| CCL4/MIP1β ↓ | |||||
| CCL5/RANTES ↓ | |||||
|
Human T cells (MS patient) |
IFN-β |
IFN-β |
nd |
CCL3/MIP1α ↓ |
47 |
| CCL5/RANTES ↓ | |||||
| CCR5 ↓ | |||||
|
Mouse |
MCMV infection |
IFN-I |
nd |
CCL2/MCP1 ↑ |
49 |
| CCL3/MIP1α ↑ |
50 |
||||
| CCL7/MCP3 ↑ |
51 |
||||
| CCL12 ↑ |
|
||||
|
Mouse liver |
MCMV infection |
IFN-γ |
nd |
CXCL9/MIG ↑ |
49 |
|
Mouse brain |
LCMV infection |
IFN-γ |
nd |
CCL2/MCP1 ↑ |
55 |
| CCL3/MIP1α ↑ | |||||
| CCL5/RANTES ↑ | |||||
| CXCL10/IP10 ↑ | |||||
|
Mouse cornea |
HSV-1 |
IFN-α |
nd |
CCL2/MCP1 ↑ |
34 |
|
Mouse |
Vaccinia virus |
IFN-I, IFN-γ |
nd |
CXCL9/MIG ↑ |
134 |
| West Nile virus |
IFN-I |
nd |
CCL2/MCP1 ↑ |
135 |
|
| CCL5/RANTES ↑ | |||||
| CXCL10/IP10 ↑ | |||||
| Influenza virus |
IFN-I |
nd |
CXCL1/KC ↓ |
23 |
|
|
Streptococcus pneumoniae |
CXCL2/MIP2 ↓ |
||||
|
Mouse peritoneal cavity |
Listeria monocytogenes |
IFN-I |
nd |
CCL2/MCP1 ↑ |
42 |
| nd |
STAT1 (macrophages) |
CCL3/MIP1α ↓ |
26 |
||
| STAT1 (DC) |
CCL2/MCP1 ↑ |
||||
| CCL5/RANTES ↑ | |||||
| STAT1 (T cells) |
CCL2/MCP1 ↑ |
||||
| CCL5/RANTES ↑ | |||||
|
Mouse |
Francisella tularensis |
IFN-γ |
nd |
CCL2/MCP1 ↑ |
52 |
| Polymicrobial peritonitis (CASP) |
IFN-I |
nd |
CCL2 ↓ |
78 |
|
| Polymicrobial peritonitis (CLP) |
IFN-I |
nd |
CXCL10 ↑ |
53 |
|
|
Trypanosoma cruzi |
IFN-γ |
nd |
CXCL9/MIG ↑ |
136 |
|
| CXCL10/IP10 ↑ | |||||
|
Paracoccidioides brasiliensis |
IFN-γ |
nd |
CCL5/RANTES ↑ |
137 |
|
| CXCL1/KC/GROα ↓ | |||||
| CCL3/MIP1α ↓ | |||||
|
Candida albicans |
IFN-I |
nd |
CCL2/MCP1 ↑ |
71 |
|
| CXCL1/KC/GROα ↑ | |||||
|
Mouse thyroid gland |
IFN-γ transgene (thyroid gland) |
IFN-γ |
nd |
CXCL9/MIG ↑ |
56 |
| CXCL10/IP10 ↑ | |||||
| CCL4/MIP1β ↑ | |||||
| CCL5/RANTES ↑ | |||||
| CXCL11/I-TAC ↑ | |||||
|
Mouse mast cells |
Imiquimod |
IFN-I |
nd |
CCL2/MCP1 ↑ |
59 |
|
Mouse |
TNF |
IFN-I |
nd |
CXCL9/MIG ↑ |
27 |
| CXCL10/IP10 ↑ | |||||
| CXCL11/I-TAC ↑ | |||||
| Allergic asthma |
IFN-γ |
STAT1 |
CXCL9/MIG ↑ |
58 |
|
| CXCL10/IP10 ↑ | |||||
| ConA-induced hepatitis |
IFN-γ |
STAT1 |
CXCL5/ENA-78 ↑ |
138 |
|
| CXCL9/MIG ↑ | |||||
| CXCL10/IP10 ↑ | |||||
| CXCL11/I-TAC ↑ | |||||
|
Mouse (astrocytes) |
EAE |
IFN-γ |
nd |
CXCL10/IP10 ↑ |
57 |
| Human (MS patient) | IFN-β | IFN-β | nd | CCL2/MCP1 ↑ |
139 |
| CXCL10/IP10 ↑ |
nd, not determined