Figure 1. Interaction of STAT3 with DNMT1. (A) STAT3 binds specific gene promoters and activates transcription. (B) Acetylation of STAT3 at K685 enables it to interact with DNMT1 and targets DNMT1 to methylate CpGs in certain gene promoters. Note that the schema is drawn as a dimeric STAT3-DNMT1 complex, although the stoichiometry was not investigated in the study. Other post-translational modifications, such as phosphorylation have also been omitted.