Table 1. siRNA targeting STAT3 and STAT5 in cancer.

Preclinical cancer models	Target protein	Key findings
Laryngeal cancer23,30	STAT3	Decreased STAT3 expression, reduced tumor volume, suppressed growth and induced apoptosis
Pancreatic cancer26	STAT3	Inhibited cell proliferation, induced apoptosis, downmodulated STAT3 target genes and suppressed tumor growth
Breast cancer27	STAT3	Reduced STAT3 target gene expression and caused significant reduction in tumor volume
Esophageal carcinoma31	STAT5	Decreased proliferation, invasion and metastasis in association with an induction in apoptosis and an increase in the G0/G1 phase
Acute myeloid leukemia32	STAT5	Inhibited cell proliferation and survival