Table 2. Comparison of two genetic mouse models of sustained cardiac STAT3 activation.
| |
MODEL |
|||
|---|---|---|---|---|
| |
Y757F |
SOCS3 KO |
||
| Baseline* | Stress (MI) | Baseline | Stress (TAC) | |
| pY STAT3 |
≅ |
↑ (> > WT)** |
↑ |
↑ (> WT) |
| pS STAT3 |
nr |
nr |
nr |
nr |
| STAT3 |
≅ |
↑ (later times) |
≅ |
≅ |
| pYSTAT1 |
≅ |
≅ |
≅ (initial screening) |
nr |
| STAT1 |
≅ |
≅ |
≅ |
nr |
| PI3K/AKT |
≅ |
≅ (↓) |
↑ (AKT)† |
↑ (AKT) (> WT?) |
| SHP2/MAPK |
≅ |
≅ (modest ↑) |
↑ (ERK, p38)† |
↑ (ERK) (> WT?) |
| Phenotype | Normal cardiac function and morphology | ↑ mortality ↑ LV rupture ↑ cardiac Inflammation Heart failure |
Cardiac hypertrophy Heart failure (No cm disarray, necrosis, apoptosis, inflammation or interstitial fibrosis) |
Cardiac hypertrophy Cardiac dysfunction |
*
At 3 mo
**
Both level and duration
† At 15 weeks, but not 8 weeks. Symbols/abbreviations: ≅, no difference compared with wild type; cm, cardiac myocyte; nr, not reported; WT, wild type; ↑, increase; ↓, decrease.