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. 2013 May 13;110(22):9124–9129. doi: 10.1073/pnas.1220591110

Fig. 4.

Fig. 4.

Rapid increase in A/N during cue-induced reinstatement of nicotine seeking. (A) Sample AMPA and NMDA current traces from each group. A/N was significantly elevated in animals withdrawn with extinction training from nicotine self-administration compared with yoked saline animals. The initiation of cue-induced reinstatement of nicotine-seeking further elevated A/N at t = 15. (B) Decay time (time to 37% decay) for NMDA currents in nicotine-extinguished animals was significantly increased in nicotine-extinguished animals (t = 0) as well as animals at t = min compared with yoked saline animals. N in parentheses is number of animals. The number in bars is number of cells recorded in each condition. *P < 0.05 compared with yoked saline animals at t = 0 (white bar); +P < 0.05 compared with t = 0.