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Enrichment of higher Env IgA/IgG ratio in infected RV144 vaccinees. The ratio of IgA/IgG HIV-1–specific Env binding was calculated for each sample and analyzed for differences between infected and uninfected vaccine recipients in the case control study. There was a significantly greater number of infected vaccinees with IgA/IgG ratio >1e-02 (A1 Congp140 Env) than uninfected vaccinees (weighted logistic regression using the method as reported in ref. 2; P = 0.0015).
