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Alignment of scorpion DDH peptides and calcines. Disulfide pairings are indicated above the sequences with square brackets, with the two solid lines indicating disulfides comprising the DDH motif and the dotted line indicating the third disulfide of the ICK motif. Triangles above the sequences highlight the Leu and Arg residues important for calcine activity; stars above the sequences highlight the Arg and Trp residues involved in scorpion DDH peptide activity at RyRs.
