Table 1.
Immunodominant regions of the DENV polyprotein
| Antigenic region | Epitope sequence | Proteome location | Sero type | HLA allele | No. of responders | T-cell response (SFC) |
|
| No. | Total | ||||||
| 1 | TPEGIIPAL | 1978 | 1,4 | B*0702 | 1 | 183 | 10,671 |
| TPEGIIPALF | 1978 | 1,4 | B*3501 | 9 | 2,213 | ||
| TPEGIIPSM | 1978 | 2 | B*3501, B*5301 | 5 | 2,717 | ||
| TPEGIIPSMF | 1978 | 2 | B*0702, B*3501 | 7 | 1,772 | ||
| TPEGIIPTLF | 1978 | 4 | B*3501,B*0702,B*5301 | 11 | 2,914 | ||
| YTPEGIIPTL | 1977 | 4 | A*0206 | 1 | 872 | ||
| 2 | GEARKTFVDL | 2005 | 2 | B*4001 | 3 | 1,405 | 5,005 |
| GEARKTFVEL | 2005 | 1 | B*4001 | 3 | 1,330 | ||
| GEQRKTFVEL | 2005 | 4 | B*4001 | 2 | 1,050 | ||
| GESRKTFVEL | 2005 | 3 | B*4001 | 3 | 1,220 | ||
| 3 | LPVWLAHKVA | 2020 | 3 | B*3501 | 1 | 23 | 4,157 |
| LPVWLAYKV | 2020 | 2 | B*5301, B*5101 | 2 | 923 | ||
| LPVWLAYKVA | 2020 | 2 | B*3501 | 7 | 2,427 | ||
| LPVWLAYRVA | 2020 | 2 | B*5101 | 1 | 470 | ||
| LPVWLSYKV | 2020 | 1 | B*5101 | 1 | 313 | ||
| 4 | HPGAGKTKRY | 1672 | 2 | B*3501 | 10 | 3,047 | 3,047 |
| 5 | NPEIEDDIF | 1653 | 2 | B*3501 | 10 | 3,390 | 3,390 |
| 6 | DTTPFGQQR | 2840 | 1,2,3,4 | A*6801, A*3301 | 8 | 3,260 | 3,260 |
| 7 | MSFRDLGRVM | 1176 | 2 | B*3501 | 8 | 3,250 | 3,250 |
| 8 | ATGPILTLW | 2444 | 4 | B*5801 | 2 | 938 | 3,089 |
| ATGPISTLW | 2444 | 2 | B*5801 | 2 | 236 | ||
| ATGPITTLW | 2444 | 3 | B*5801 | 1 | 505 | ||
| ATGPLTTLW | 2444 | 1 | B*5801 | 1 | 275 | ||
| ATGPVLTLW | 2444 | 4 | B*5801 | 2 | 390 | ||
| LATGPVLTLW | 2443 | 4 | B*5301 | 1 | 745 | ||
| 9 | CLIPTAMAF | 108 | 4 | B*1501 | 1 | 67 | 2,815 |
| MLIPTAMAF | 108 | 2 | B*3501 | 7 | 2,748 | ||
| 10 | VATTFVTPM | 2290 | 2 | B*3501 | 8 | 2,777 | 2,777 |
| 11 | KPRICTREEF | 2885 | 1 | B*0702 | 1 | 340 | 2,756 |
| KPRLCTREEF | 2885 | 3 | B*0702 | 1 | 350 | ||
| NPRLCTREEF | 2885 | 4 | B*0702 | 1 | 365 | ||
| RPRLCTREEF | 2885 | 3 | B*0702 | 4 | 501 | ||
| TPRMCTREEF | 2885 | 2 | B*0702, B*3501 | 5 | 1,200 | ||
| 12 | VPLLAIGCY | 2338 | 2 | B*3501 | 7 | 1,520 | 2,603 |
| VPLLAMGCY | 2338 | 4 | B*3501 | 1 | 1,083 | ||
| 13 | MSYSMCTGKF | 578 | 2 | B*3501 | 6 | 2,553 | 2,553 |
| 14 | DPASIAARGY | 1768 | 1,2,3 | B*3501 | 9 | 2,383 | 2,383 |
| 15 | IANQATVLM | 2315 | 2 | B*3501 | 7 | 1,518 | 1,518 |
| 16 | APTRVVAAEM | 1700 | 2,3,4 | B*0702, B*3501 | 8 | 1,623 | 2,230 |
| APTRVVASEM | 1700 | 1 | B*0702 | 5 | 607 | ||
| 17 | TPMLRHTIEN | 2296 | 3,4 | B*0702 | 2 | 388 | 2,123 |
| 18 | MLVTPSMTM | 274 | 3 | B*3501 | 8 | 1,735 | 1,735 |
| 19 | FTMRHKKATY | 2738 | 2 | B*3501 | 4 | 1,723 | 1,723 |
| 20 | FTILALFLAH | 248 | 3 | B*3501 | 8 | 1,715 | 1,715 |
| 21 | WHYDQDHPY | 2787 | 2 | B*3501 | 5 | 1,628 | 1,628 |
| 22 | MALKDFKEF | 2083 | 4 | B*3501 | 7 | 1,497 | 1,497 |
| 23 | LMKITAEWLW | 2868 | 2 | B*5301 | 1 | 423 | 1,417 |
| MEITAEWLW | 2869 | 3 | B*5801 | 1 | 583 | ||
| VMGITAEWLW | 2868 | 3 | B*5301 | 1 | 410 | ||
| 24 | TETTILDVDL | 2266 | 4 | B*4001 | 2 | 1,413 | 1,413 |
| 25 | GEFRLRGEQR | 1999 | 4 | B*4001 | 3 | 1,373 | 1,373 |