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. 2013 Jun 13;86(2):203–216.

Table 1. The various conflicting theories of synaesthesia etiology.

Theory Author Explanation Additional Notes
Hyperconnectivity Theory Ramachandran and Hubbard Caused by increased connectivity between cortical regions. Connectivity is likely caused by failure of cortical pruning of neurons.
Disinhibition-unmasking hypothesis Grossenbacher and Lovelace Caused by a decreased level of feedback from inhibitory cortical areas. This theory suggests constitutive inhibitory cortical feedback is present in everyone.
Learned association theory Calkin Suggests that synesthetic links are caused by learned associations early in life. Discredited due to genetic component and increased incidence in women.
Awareness theory Cytowic Suggests that synesthesia is part of a normal perceptual process, and the phenomenon is caused by a failure of our brain to suppress the concurrent which he hypothesizes occurs in everyone. Implicates the limbic system as important especially the hippocampus.
Neonatal synaesthesia Maurer This theory suggests that humans are all born with synesthesia-like tendencies, which in “normal” people are lost through age. Widely refuted. Discussed at length later.