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. 2013 Jun 13;86(2):217–233.

Table 2. Huntingtin Interacting Proteins [39,143-145].

Name Protein function Htt binging region Influence of mu HTT
Transcription
CA150 Transcription activator Unknown None
CBP Transcription activator Amino acids 1-588 Enhances
CtBP Transcription repressor Unknown Decreases
HYP-A, B RNA splicing factors Polyproline Enhances
HYP-C Transcription factor Polyproline Enhances
NCOR Transcription repressor Amino acids 1-171 Enhances
NF-ĸB Transcription factor HEAT repeats Unknown
SP1 Transcription activator Amino acids 1-171 Enhances
TAFII130 Transcription activator Amino acids 1-480 None
TBP Basal transcription factor Unknown Unknown
P53 Transcription factor Polyproline None
REST-NRSE Trascription suppressor Amino acids 1-548 Decreases
Trafficking and endocytosis
HAP1 Trafficking, endocytosis Amino acids 1-230 Enhances
HIP1 Endocytosis, pro-apoptotic Amino acids 1-540 Decreases
HIP14 Trafficking, endocytosis Amino acids 1-550 Decreases
PACSIN1 Endocytosis Polyproline Enhances
Phosphatidylethanolamine Phospholipids Amino acids 171-287 Enhances
PI(3,4,5)P3
PSD-905 Synaptic scaffolding Unknown Decreases
Signaling
Calmodulin Calcium-binding regulatory protein Unknown Enhances
CIP-4 Cdc42-related signaling Amino acids 1-152 Enhances
FIP2 (HYP-L) GTPase Rab8 interactor Amino acids 1-550 Unknown
GRb2 Growth factor signaling Polyproline Unknown
IP31 Calcium release channel Amino acids 1-158 Enhances
SH3GL3 Endocytosis and vesicle recycling Polyproline Enhances
RasGAP Ras GTPase-activating protein Polyproline Unknown
Metabolism
Cystathionine b-synthase Generation of cysteine Amino acids 1-171 None
GAPDH Glycolitic enzyme Polyproline Enhances
gp78 ER membrane-anchored ubiquitin ligase HEAT repeats 2/3 Enhances
HIP2 Ubiquitin-conjugated enzyme Amino acids 1-540 None
Protein Synthesis
Gnb211 Translation (indirect,) ribosomal protein Unknown Decreases
Myo5a RNA transport to spines Unknown Decreases
Rps6 Translation (direct), Ribosomal protein Unknown Decreases
Prkra Translation (indirect), PKR regulation Unknown Decreases

Abbreviations: CA150, co-activator 150; CBP, (cAMP-response element binding protein) binding protein; CIP-4, cdc42-interacting protein 4; Co-IP, co-immunoprecipitation; CtBP, C-terminal-binding protein; FIP2, for 14.7K interacting protein; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; Gnb2l1, guanine nucleotide-binding protein (G protein) polypeptide 2-like 1; gp78, glycoprotein 78; GRB2, growth factor receptor-binding protein 2; GST, glutathione S-transferase; HAP1, htt-associated protein 1; HIP, htt-interacting protein; HYP, htt-yeast partner; IP31, inositol (1,4,5)-trisphosphate receptor type 1; Myo5a, myosin V;A NCOR, nuclear receptor co-repressor; NF-kB, nuclear factor-kB transcription factor; PACSIN1, protein kinase C and casein kinase substrate in neurons 1; [PI(3,4,5)P3] phosphoinositol, (PI) 3,4-bisphosphate, PI 3,5-bisphosphate, and PI 3,4,5-triphosphate; PKR, double-stranded RNA-activated protein kinase; Prkra, interferon inducible double-stranded RNA-dependent protein kinase activator A; PSD- 95, postsynaptic density 95; RasGAP, Ras GTPase-activating protein; REST–NRSE, the repressor element-1 transcription factor–the neuron restrictive silencer element; Rps6, ribosomal protein S6; SH3GL3, SH3-containing GRB2-like protein 3; SP1, specificity protein-1; TAFII130, TBP-associated factor; TBP, TATA box binding protein.