Table 2. Summary of the top biological functions identified from IPA for the genes displaying a significant difference in expression between CNS PNETs predicted to have WNT/β-catenin pathway activation and the rest of the cohort.
| Name | P-value | Number of molecules |
|---|---|---|
|
Diseases and disorders | ||
| Dental disease | 1.10E-03-1.65E-02 | 2 |
| Antimicrobial disease | 3.32E-03-3.32E-03 | 1 |
| Cancer | 3.32E-03-4.67E-02 | 20 |
| Cardiovascular disease | 3.32E-03-9.92E-03 | 2 |
| Developmental disorder |
3.32E-03-4.55E-02 |
6 |
|
Molecular and cellular functions | ||
| Cell cycle | 1.08E-05-2.95E-02 | 5 |
| Cellular compromise | 2.99E-04-3.59E-02 | 5 |
| Cellular development | 4.78E-04-4.75E-02 | 18 |
| Cellular growth and proliferation | 9.59E-04-4.87E-02 | 17 |
| Cell morphology |
1.98E-03-4.23E-02 |
4 |
|
Physiological system development and function | ||
| Digestive system development and function |
1.22E-06-2.62E-02 |
6 |
| Organ development |
1.22E-06-3.27E-02 |
8 |
| Haematological system development and function |
1.08E-05-4.23E-02 |
5 |
| Humoral immune response |
1.08E-05-9.59E-04 |
2 |
| Tissue development | 8.83E-05-4.59E-02 | 11 |
Abbreviations: CNS PNET=central nervous system primitive neuroectodermal tumour; IPA=ingenuity pathway analysis.