Table 1. Glioma risk and rs78378222 by morphology in the French case–control series.
| Grade | Histology | N | OR | 95% CI | P-value |
|---|---|---|---|---|---|
| |
Low-grade astrocytoma |
81 |
2.8 |
1.0–8.2 |
0.05 |
| II |
Oligoastrocytoma |
97 |
1.7 |
0.5–5.8 |
0.36 |
| |
Oligodendroglioma |
218 |
2.9 |
1.4–5.8 |
1.8 × 10−3 |
| |
Anaplastic astrocytoma |
48 |
4.9 |
1.7–14.6 |
1.3 × 10−3 |
| III |
Anaplastic oligoastrocytoma |
100 |
2.3 |
0.8–6.5 |
0.12 |
| |
Anaplastic oligodendroglioma |
179 |
1.6 |
0.6–4.0 |
0.36 |
| IV | GBM | 424 | 2.8 | 1.6–5.0 | 1.0 × 10−4 |
Abbreviations: CI=confidence interval; GBM=glioblastoma multiforme; OR=odds ratio.The analysis is based directly on genotyped data for 1147 cases and 1827 controls. Per allele odds ratios are shown with the risk allele for all tests being the C-allele with the reference being AA homozygotes.