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Prognostic effects of RKIP expression in tumour centre stratified by stage and therapy. (A) No impact on prognosis was observed in early-stage patients (P=0.9585). (B) Stage III patients with maintained RKIP expression derived a significant survival benefit (P=0.01). (C) The prognostic value of RKIP in the tumor centre was maintained in stage III CRC patients receiving adjuvant chemotherapy (P=0.002).
