Table 3. Expression of RKIP in the tumor front and association with clinicopathological features (n=187).
| |
RKIP (n, %) |
|
|
|---|---|---|---|
| Feature | Negative (<10%) | Positive (⩾10%) | P-value |
|
Gender (n=186) | |||
| Male | 43 (50.0) | 49 (49.0) | 0.8918 |
| Female |
43 (50.0) |
51 (51.0) |
— |
|
Age (years) | |||
| Mean (min, max) |
67.6 (35, 89) |
68.6 (36, 93) |
0.5366 |
|
Tumor size (mm) | |||
| Mean (min, max) |
4.9 (1, 12) |
4.2 (1.2, 3.0) |
0.0229 |
|
Histological subtype (n=187) | |||
| Non-mucinous | 73 (84.9) | 90 (89.1) | 0.3893 |
| Mucinous |
13 (15.1) |
11 (10.9) |
— |
|
Tumor location (n=186) | |||
| Left-side | 54 (63.5) | 61 (60.4) | 0.6518 |
| Right-side | 13 (15.3) | 13 (12.9) | — |
| Rectum |
18 (21.2) |
27 (26.7) |
— |
|
Tumor grade (n=187) | |||
| G1–2 | 48 (55.8) | 70 (69.3) | 0.0567 |
| G3 |
38 (44.2) |
31 (30.7) |
— |
|
pT (n=187) | |||
| pT1–2 | 21 (24.4) | 28 (27.7) | 0.6086 |
| pT3–4 |
65 (75.6) |
73 (72.3) |
— |
|
pN (n=187) | |||
| pN0 | 39 (45.4) | 56 (55.5) | 0.1687 |
| pN1–2 |
47 (54.7) |
45 (44.6) |
— |
|
pM (n=186) | |||
| pM0 | 75 (87.2) | 94 (94.0) | 0.1091 |
| pM1 |
11 (12.8) |
6 (6.0) |
— |
|
V (n=187) | |||
| V+ | 18 (20.9) | 11 (10.9) | 0.0587 |
| V− |
68 (79.1) |
90 (89.1) |
— |
|
L (n=187) | |||
| L+ | 41 (47.7) | 34 (33.7) | 0.0514 |
| L− |
45 (52.3) |
67 (66.3) |
— |
|
Tumor budding (n=148) | |||
| Low-grade | 50 (74.6) | 40 (49.4) | 0.0017 |
| High-grade |
17 (25.4) |
41 (50.6) |
— |
|
Tumor growth pattern (n=187) | |||
| Infiltrating | 68 (79.1) | 66 (65.4) | 0.038 |
| Pushing |
18 (20.9) |
35 (34.7) |
— |
|
Mismatch repair status (n=186) | |||
| Proficient | 77 (89.5) | 96 (96.0) | 0.0847 |
| Deficient |
9 (10.5) |
4 (4.0) |
— |
|
B-RAF mutation (V600E) (n=180) | |||
| Wild type | 71 (86.6) | 92 (93.9) | 0.0957 |
| Mutated |
11 (13.4) |
6 (6.1) |
— |
|
KRAS mutation (codon 12/13), (n=171) | |||
| Wild type | 54 (71.1) | 59 (62.1) | 0.2194 |
| Mutated |
22 (29.0) |
36 (37.9) |
— |
|
Hazard ratio for death with loss of RKIP (n=186) | |||
| HR (95%CI) |
1.37 (0.84–2.22) |
0.2082 |
|
|
Adjuvant therapy (n=187) | |||
| None | 30 (43.5) | 56 (47.5) | 0.5983 |
| Treated | 39 (56.5) | 62 (52.5) | — |