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. 2013 Apr 11;108(10):2164–2171. doi: 10.1038/bjc.2013.143

Table 4. Overall detection rates of rare BRAF mutations with different methods.

Reference Pyrosequencing Pyrosequencing/Sanger sequencing COBAS Immunohistochemistry BRAF V600E
Patients
92.9% (13/14a)
100% (14/14)
50.0% (7/14)
21.4% (3/14)
Samples 95.5% (42/44b) 100% (44/44) 44% (8/18) 27.8% (5/18)
a

Including two patients where mutations could not be fully classified.

b

Including six samples where mutations could not be fully classified.