Table 3. Performance characteristics of the hexaplex and pentaplex panels for the identification of dMMR tumoursa (n=148).
| Panel | No. of unstable markers | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) |
|---|---|---|---|---|---|
| Hexaplex |
⩾3 |
85.7 (75.9–92.6) |
100.0 (94.9–100.0) |
100.0 (94.6–100.0) |
86.6 (77.3–93.1) |
| |
⩾2 |
90.9 (81.9–96.2) |
97.2 (90.2–99.7) |
97.2 (90.2–99.7) |
90.7 (81.0–95.6) |
| |
⩾1 |
96.1 (89.0–99.2) |
97.2 (90.2–99.7) |
97.4 (90.8–99.7) |
95.8 (88.3–99.1) |
| Pentaplex |
⩾3 |
75.3 (64.1–84.4) |
100.0 (94.9–100.0) |
100.0 (93.8–100.0) |
78.9 (69.0–86.8) |
| |
⩾2 |
85.7 (75.9–92.6) |
100.0 (94.9–100.0) |
100.0 (94.6–100.0) |
86.6 (77.3–93.1) |
| ⩾1 | 92.2 (83.8–97.1) | 97.2 (90.2–99.7) | 97.3 (90.5–99.7) | 92.0 (83.4–97.0) |
Abbreviations: CI=confidence interval; dMMR=defective DNA mismatch repair; NPV=negative predictive value; PPV=positive predictive value.
a
Results are expressed as percentages, with 95% CIs in brackets.