Table 5. Performance characteristics of individual markers for the identification of dMMR tumoursa (n=148).
| Marker | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) |
|---|---|---|---|---|
| BAT25 |
74.4 (63.6–82.8) |
98.6 (91.6–100.0) |
98.3 (90.2–100.0) |
77.5 (67.8–85.0) |
| BAT26 |
84.6 (74.9–91.1) |
98.6 (91.5–100.0) |
98.5 (91.3–100.0) |
85.0 (75.4–91.4) |
| BAT40 |
92.2 (83.7–96.7) |
97.1 (89.3–99.8) |
97.3 (90.0–99.8) |
91.7 (82.7–96.4) |
| NR21 |
70.1 (59.1–79.2) |
100.0 (93.7–100.0) |
100.0 (92.1–100.0) |
75.0 (65.2–82.8) |
| NR22 |
64.1 (53.0–73.9) |
100.0 (93.8–100.0) |
100.0 (91.5–100.0) |
71.4 (61.8–79.5) |
| NR27 | 82.1 (72.0–89.1) | 100.0 (93.7–100.0) | 100.0 (93.2–100.0) | 83.1 (73.5–89.8) |
Abbreviations: CI=confidence interval; dMMR=defective DNA mismatch repair; NPV=negative predictive value; PPV=positive predictive value.
a
Results are expressed as percentages, with 95% CIs in brackets.