Table 6. Performance characteristics of the hexaplex and pentaplex panels for the identification of non-CRC-dMMR and MSH6-deficient tumoursa, b (n=148).
| |
Hexaplex |
Pentaplex |
||
|---|---|---|---|---|
| Tumour | Sensitivity (95% CI) | Specificity (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) |
| CRC |
100.0 (90.0–100.0) |
100.0 (90.3–100.0) |
100.0 (90.0–100.0) |
100.0 (90.3–100.0) |
| Non-CRC |
92.9 (80.5–98.5) |
94.3 (80.9–99.3) |
85.7 (71.5–94.6) |
94.3 (80.9–99.3) |
| Non-MSH6 |
96.6 (88.1–99.6) |
— |
94.8 (85.6–98.9) |
— |
| MSH6 |
94.7 (74.0–99.9) |
— |
84.2 (60.4–96.6) |
— |
| All | 96.1 (89.0–99.2) | 97.2 (90.2–99.7) | 92.2 (83.8–97.1) | 97.2 (90.2–99.7) |
Abbreviations: CI=confidence interval; CRC=colorectal cancer; dMMR=defective DNA mismatch repair.
a
Results are expressed as percentages, with 95% CIs in brackets
b
Tumours showing instability for ⩾1 markers were considered as MSI.