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| Parameter, mean (CV%) | Neratinib 240 mg + paclitaxel 80 mg m−2 (n=22) | Monotherapy of neratinib 240 mg (n=3) (Wong et al, 2009) |
|---|---|---|
|
Cmax, ng ml−1 |
68.6 (47) |
73.5 (37) |
| AUC0–24, ng h ml−1 | 1027 (49) | 939 (34) |
Abbreviations: AUC0−24= area under the curve from treatment initiation to 24 h; CV%=coefficient of variation; Cmax=maximum plasma concentration.
