Table 1b. Clinical characteristics of colorectal cancer cases in the CRUMS cohort.
| |
Quadruple index |
KRAS |
BRAF |
PIK3CAExon20 |
PTEN |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | Negative | Positive | P-value | Wt | Mutant | P-value | Wt | Mutant | P-value | Wt | Mutant | P-value | Normal | Loss | P-value | |
| Frequency (%) |
414 |
227 (56.0) |
178 (44.0) |
|
331 (80.5) |
80 (19.5) |
|
356 (86.8) |
54 (13.2) |
|
396 (97.8) |
9 (2.2) |
|
352 (85.9) |
58 (14.1) |
|
| Age, n (%) |
|
|
|
0.572 |
|
|
0.287 |
|
|
0.017 |
|
|
0.226 |
|
|
0.807 |
| <59 |
68 (16.4) |
41 (18.1) |
23 (12.9) |
|
55 (16.6) |
13 (16.3) |
|
64 (18.0) |
3 (5.6) |
|
66 (16.7) |
0 (0.0) |
|
59 (16.8) |
7 (12.1) |
|
| 60–69 |
82 (19.8) |
44 (19.4) |
36 (20.2) |
|
65 (19.6) |
15 (18.8) |
|
70 (19.7) |
9 (16.7) |
|
77 (19.4) |
4 (44.4) |
|
70 (19.9) |
11 (19.0) |
|
| 70–79 |
162 (39.1) |
88 (38.8) |
73 (41.0) |
|
136 (41.1) |
26 (32.5) |
|
131 (36.8) |
31 (57.4) |
|
155 (39.1) |
3 (33.3) |
|
137 (38.9) |
24 (41.4) |
|
| >80 |
102 (24.6) |
54 (23.8) |
46 (25.8) |
|
75 (22.7) |
26 (32.5) |
|
91 (25.6) |
11 (20.4) |
|
98 (24.7) |
2 (22.2) |
|
86 (24.4) |
16 (27.6) |
|
| Sex, n (%) |
|
|
|
0.179 |
|
|
0.622 |
|
|
0.313 |
|
|
0.209 |
|
|
0.313 |
| Men |
233 (56.3) |
135(59.5) |
94 (52.8) |
|
188 (56.8) |
43 (53.8) |
|
204 (57.3) |
27 (50.0) |
|
225 (56.8) |
7 (77.8) |
|
201 (57.1) |
29 (50.0) |
|
| Women |
181 (43.7) |
92 (40.5) |
84 (47.2) |
|
143 (43.2) |
37 (46.3) |
|
152 (42.7) |
27 (50.0) |
|
171 (43.2) |
2 (22.2) |
|
151 (42.9) |
29 (50.0) |
|
| Tumour site, n (%) |
|
|
|
<0.001 |
|
|
0.100 |
|
|
<0.001 |
|
|
0.700 |
|
|
0.682 |
| Right-sided colon |
132 (32.2) |
46 (20.5) |
83 (46.9) |
|
98 (30.0) |
34 (42.5) |
|
88 (25.0) |
43 (79.6) |
|
124 (31.6) |
4 (44.4) |
|
133 (32.4) |
17 (29.8) |
|
| Left-sided colon |
126 (30.7) |
82 (36.6) |
42 (23.7) |
|
104 (31.8) |
21 (26.3) |
|
118 (33.5) |
6 (11.1) |
|
122 (31.1) |
2 (22.2) |
|
110 (31.5) |
16 (28.1) |
|
| Rectum |
152 (37.1) |
96 (42.9) |
52 (29.4) |
|
125 (38.2) |
25 (31.3) |
|
146 (41.5) |
5 (9.3) |
|
146 (37.2) |
3 (33.3) |
|
126 (36.1) |
24 (42.1) |
|
| Stage, n (%) |
|
|
|
0.162 |
|
|
0.030 |
|
|
0.744 |
|
|
0.293 |
|
|
0.800 |
| I |
63 (15.5) |
41 (18.6) |
19 (10.8) |
|
57 (17.6) |
4 (5.1) |
|
55 (15.8) |
7 (13.0) |
|
60 (15.4) |
2 (25.0) |
|
53 (15.4) |
10 (17.5) |
|
| II |
164 (40.4) |
88 (39.8) |
71 (40.3) |
|
131 (40.4) |
32 (40.5) |
|
137 (39.4) |
24 (44.4) |
|
152 (39.1) |
5 (62.5) |
|
143 (41.4) |
20 (35.1) |
|
| III |
87 (21.4) |
44 (19.9) |
43 (24.4) |
|
67 (20.7) |
20 (25.3) |
|
74 (21.3) |
13 (24.1) |
|
87 (22.4) |
0 (0.0) |
|
71 (20.6) |
14 (24.6) |
|
| IV |
92 (22.7) |
48 (21.7) |
43 (24.4) |
|
69 (21.3) |
23 (29.1) |
|
82 (23.6) |
10 (18.5) |
|
90 (23.1) |
1 (12.5) |
|
78 (22.6) |
13 (22.8) |
|
| Histology type, n (%) |
|
|
|
0.023 |
|
|
0.515 |
|
|
<0.001 |
|
|
0.239 |
|
|
0.852 |
| Non-mucinous |
348 (85.3) |
198 (88.8) |
142 (80.7) |
|
275 (84.6) |
70 (87.5) |
|
310 (88.6) |
35 (64.8) |
|
333 (85.2) |
8 (100.0) |
|
295 (85.0) |
49 ( 86.0) |
|
| Mucinous | 60 (14.7) | 25 (11.2) | 34 (19.3) | 50 (15.4) | 10 (12.5) | 40 (11.4) | 19 (32.2) | 58 (14.8) | 0 (0.0) | 52 (15.0) | 8 (14.0) | |||||
Abbreviations: CRUMS=Colorectal Cancer in Umeå Study; Wt=wild-type.
Following numbers of missing cases were present in CRUMS: Quadruple Index, 9; KRAS mutation status, 3; BRAF mutation status, 4; PIK3CA mutation status, 9; PTEN mutation status, 4; Tumour site, 4; Stage, 8; Histology type, 6; Adjuvant chemotherapy, 6; Preoperative, 3. Kruskall–Wallis test was used for continuous variables, χ2-test or Fisher's exact test used for categorical variables.