Table 3a. Cox regression of colorectal cancer cases in the NSHDS cohort.

N	UnivariateHR (CI 95%)	MultivariateHR (CI 95%)
Quadruple Index
172	1.978 (1.251–3.128)	1.308 (0.787–2.174)
KRAS
179	1.325 (0.773–2.271)	0.798 (0.443–1.438)
BRAF
196	2.428 (1.490–3.956)	1.998 (1.165–3.426)
PIK3CA Exon20
186	0.657 (0.091–4.739)	0.285 (0.038–2.141)
PTEN
184	1.555 (0.859–2.816)	1.289 (0.699–2.376)

Abbreviations: Cl=confidence interval; HR=hazard ratio, NSHDS=Northern Sweden Health Disease Study.

HR determined by Cox proportional hazard models, adjusted for sex, age, tumour site and tumour stage.