Table 4. Cox multivariate regression analysis of variables in relation to disease-specific survival.
| (A) | |||
|---|---|---|---|
| Variable | Hazard ratio | 95% CI | P value |
|
Vascular invasion status | |||
| Negative | 1 | ||
| Positive |
1.191 |
0.764–2.885 |
0.244 |
|
TNM stage | |||
| 0–II | 1 | ||
| III–IV |
2.506 |
1.496–4.196 |
<0.001 |
|
CC3 tumour | |||
| Low | 1 | ||
| High |
0.808 |
0.341–1.917 |
0.629 |
|
CC3 tumour-associated stroma expression | |||
| Low | 1 | ||
| High |
0.479 |
0.229–1.003 |
0.051 |
|
Cleaved PARP tumour | |||
| Low | 1 | ||
| High |
1.205 |
0.394–3.687 |
0.744 |
|
Cleaved PARP tumour-associated stroma expression | |||
| Low | 1 | ||
| High |
0 |
0 |
0.975 |
|
MHC-II tumour | |||
| Negative | 1 | ||
| Positive |
0.464 |
0.104–2.079 |
0.315 |
|
MHC-II tumour-associated stroma expression | |||
| Negative | 1 | ||
| Positive |
1.110 |
0.716–1.722 |
0.640 |
| (B) | |||
|
Vascular invasion status | |||
| Negative | 1 | ||
| Positive |
0.638 |
0.394–1.034 |
0.068 |
|
TNM stage | |||
| 0–II | 1 | ||
| III–IV |
3.733 |
2.141–6.506 |
<0.001 |
|
ITTC | |||
| Low | 1 | ||
| High |
1.310 |
0.825–2.080 |
0.253 |
|
MHC-I | |||
| Low | 1 | ||
| High |
0.549 |
0.219–1.376 |
0.201 |
|
CC3 tumour-associated stroma expression | |||
| Low | 1 | ||
| High | 0.490 | 0.299–0.804 | 0.005 |
Abbreviations: CC3=cleaved caspase-3; CI=confidence interval; ITTC=intratumoural T cells; MHC=major histocompatibility class ; PARP=poly (ADP-ribose) polymerase; TNM=Tumor, Node, Metastasis.