Table 3. Treatment-related adverse events in ⩾2 patients.
| Tremelimumab+PF-3512676 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| |
6 mg kg−1+0.05 mg kg−1 (n=3) |
10 mg kg−1+0.05 mg kg−1 (n=6) |
15 mg kg−1+0.05 mg kg−1 (n=6) |
10 mg kg−1+0.10 mg kg−1 (n=3) |
10 mg kg−1+0.15 mg kg−1 (n=3) |
|||||
| Total | Grade⩾3 | Total | Grade⩾3 | Total | Grade ⩾3 | Total | Grade ⩾3 | Total | Grade ⩾3 | |
| Any adverse event |
3 |
0 |
6 |
1 |
6 |
2 |
3 |
2 |
3 |
2 |
| Injection-site reaction |
3 |
0 |
6 |
0 |
6 |
0 |
3 |
0 |
3 |
0 |
| Influenza-like illness |
3 |
0 |
5 |
0 |
4 |
0 |
3 |
0 |
3 |
0 |
| Diarrhoea |
2 |
0 |
3 |
0 |
4 |
2 |
2 |
1 |
2 |
0 |
| Nausea |
1 |
0 |
3 |
0 |
3 |
1 |
1 |
0 |
1 |
0 |
| Rash |
1 |
0 |
3 |
0 |
2 |
0 |
2 |
1 |
0 |
0 |
| Pruritus |
1 |
0 |
1 |
0 |
4 |
0 |
1 |
1 |
0 |
0 |
| Vomiting |
1 |
0 |
3 |
0 |
2 |
1 |
0 |
0 |
0 |
0 |
| Decreased appetite |
1 |
0 |
2 |
0 |
1 |
0 |
1 |
0 |
0 |
0 |
| Injection-site haematoma |
1 |
0 |
1 |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
| Anaemia |
0 |
0 |
2 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
| Rash, generalised |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
2 |
0 |
| Abdominal pain |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
| Abdominal pain, upper |
0 |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
| Colitis |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
1 |
1 |
1 |
| Constipation |
0 |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
| Dysgeusia |
0 |
0 |
1 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
| Fatigue | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |