Table 3.
Top 84 differentially methylated genes (p≤ 0.005) ranked by statistical significance
| Symbol | Chromosome | Mean beta value in exposed/unexposed offspring (%)* |
Average % increase in methylation among exposed relative to unexposed offspring* |
P-value |
|---|---|---|---|---|
| NPR1 | 1 | 9.3/5.8 | 59.2 | 9.1 × 10−5 |
| ZNF330 | 4 | 14.6/10.8 | 34.9 | 1.5 × 10−4 |
| PANK1 | 10 | 19.2/12.7 | 51.0 | 2.5 × 10−4 |
| SCAND1 | 20 | 6.1/4.0 | 52.3 | 4.4 × 10−4 |
| GJA4 | 1 | 7.7/5.8 | 32.6 | 5.2 × 10−4 |
| UBE2D1 | 10 | 7.4/4.8 | 52.6 | 6.0 × 10−4 |
| PYGO1 | 15 | 5.5/3.8 | 44.8 | 6.5 × 10−4 |
| IL12RB2 | 1 | 6.9/5.5 | 25.3 | 6.6 × 10−4 |
| CLN8 | 8 | 17.6/10.2 | 72.4 | 9.0 × 10−4 |
| ZDHHC12 | 9 | 8.3/15.1 | −45.1 | 9.4 × 10−4 |
| STX10 | 19 | 10.7/7.5 | 42.0 | 9.8 × 10−4 |
| UBADC1 | 9 | 10.3/7.1 | 45.4 | 0.0010 |
| DCUN1D5 | 11 | 3.5/2.5 | 40.4 | 0.0011 |
| FAM14B | 14 | 14.4/9.5 | 52.1 | 0.0012 |
| TMCO1 | 1 | 7.3/4.6 | 59.8 | 0.0012 |
| ZDHHC14 | 6 | 4.0/3.3 | 23.3 | 0.0013 |
| SHMT2 | 12 | 5.8/4.0 | 47.5 | 0.0013 |
| BFSP1 | 20 | 11.1/8.4 | 33.0 | 0.0014 |
| CMTM6 | 3 | 4.1/3.2 | 26.5 | 0.0014 |
| ZNF345 | 19 | 24.6/18.6 | 32.6 | 0.0015 |
| SPATC1 | 8 | 16.5/11.8 | 40.1 | 0.0015 |
| GOLPH2 | 9 | 12.4/8.5 | 46.0 | 0.0016 |
| OAZ2 | 15 | 21.5/13.3 | 62.0 | 0.0017 |
| HSPBAP1 | 3 | 9.3/6.8 | 37.7 | 0.0017 |
| TMEM34 | 4 | 7.9/5.8 | 36.4 | 0.0018 |
| LRPPRC | 2 | 13.0/9.3 | 39.0 | 0.0019 |
| NACA | 12 | 5.7/4.0 | 43.2 | 0.0021 |
| USP52 | 12 | 7.8/5.1 | 52.2 | 0.0021 |
| ATP6V1C2 | 2 | 5.1/3.3 | 54.9 | 0.0022 |
| LUC7L | 16 | 6.0/4.8 | 26.8 | 0.0022 |
| SND1 | 7 | 7.0/4.5 | 53.9 | 0.0023 |
| SYNC1 | 1 | 23.6/11.4 | 106.6 | 0.0024 |
| DHDDS | 1 | 7.5/5.1 | 46.6 | 0.0024 |
| HSPA14 | 10 | 5.3/3.5 | 52.5 | 0.0026 |
| DNAH3 | 16 | 11.4/7.3 | 57.0 | 0.0026 |
| TNNT1 | 19 | 9.5/21.5 | −55.9 | 0.0026 |
| TSFM | 12 | 8.9/5.7 | 57.8 | 0.0026 |
| TOMM34 | 20 | 6.3/4.3 | 46.5 | 0.0027 |
| TMEM74 | 8 | 6.2/4.2 | 47.3 | 0.0028 |
| SLC45A3 | 1 | 5.5/4.0 | 38.7 | 0.0028 |
| LOC57146 | 16 | 7.1/5.2 | 36.0 | 0.0029 |
| OPA3 | 19 | 5.0/3.6 | 37.7 | 0.0029 |
| GIMAP2 | 7 | 17.0/10.5 | 62.9 | 0.0029 |
| WDR69 | 2 | 5.2/3.7 | 38.8 | 0.0031 |
| MLR2 | 10 | 10.6/8.0 | 32.5 | 0.0032 |
| LSM14A | 19 | 3.5/2.7 | 27.7 | 0.0032 |
| C1orf57 | 1 | 8.1/6.0 | 35.3 | 0.0033 |
| ZNF426 | 19 | 9.9/6.4 | 54.5 | 0.0033 |
| CYB561 | 17 | 5.5/4.1 | 32.3 | 0.0033 |
| PEX14 | 1 | 10.3/6.3 | 64.4 | 0.0035 |
| NPY1R | 4 | 11.1/8.3 | 34.2 | 0.0035 |
| SLC35A3 | 1 | 15.3/10.8 | 41.3 | 0.0035 |
| PARK7 | 1 | 17.4/11.4 | 52.5 | 0.0036 |
| UBE2V2 | 8 | 8.5/6.3 | 36.3 | 0.0037 |
| PSEN1 | 14 | 5.1/3.8 | 35.4 | 0.0037 |
| LAT | 16 | 4.9/4.2 | 18.5 | 0.0038 |
| NCOA6 | 20 | 11.7/8.8 | 32.3 | 0.0038 |
| ANKS1A | 6 | 5.4/4.1 | 30.8 | 0.0038 |
| C2orf28 | 2 | 5.9/4.4 | 36.2 | 0.0039 |
| UBXD6 | 8 | 3.8/2.9 | 31.2 | 0.0040 |
| AFF1 | 4 | 5.5/4.6 | 21.6 | 0.0041 |
| INPP5A | 10 | 19.1/13.4 | 42.6 | 0.0041 |
| TES | 7 | 4.3/3.2 | 37.2 | 0.0041 |
| CTLA4 | 2 | 33.2/39.7 | −16.4 | 0.0042 |
| SLC35B3 | 6 | 14.6/9.6 | 52.4 | 0.0042 |
| UBE2B | 5 | 8.1/5.3 | 52.0 | 0.0042 |
| PPRC1 | 10 | 12.9/10.5 | 23.5 | 0.0043 |
| PSCD3 | 7 | 6.4/4.9 | 30.8 | 0.0043 |
| KCTD3 | 1 | 16.8/11.1 | 51.1 | 0.0044 |
| MTUS1 | 8 | 8.4/6.1 | 37.5 | 0.0045 |
| IGSF3 | 1 | 7.1/5.9 | 19.2 | 0.0046 |
| ZNF211 | 19 | 6.9/5.5 | 25.9 | 0.0046 |
| TMEM128 | 4 | 27.7/21.6 | 28.4 | 0.0047 |
| ALDH6A1 | 14 | 4.9/4.0 | 23.2 | 0.0048 |
| RARRES3 | 11 | 10.5/7.6 | 39.2 | 0.0048 |
| KIAA0776 | 6 | 20.2/14.4 | 40.3 | 0.0049 |
| PFKFB2 | 1 | 9.8/6.6 | 49.0 | 0.0049 |
| HPS3 | 3 | 20.6/14.0 | 46.9 | 0.0050 |
| GCDH | 19 | 4.6/3.4 | 35.9 | 0.0051 |
| XPC | 3 | 5.8/4.0 | 44.7 | 0.0053 |
| FRAP1 | 1 | 12.9/9.8 | 31.6 | 0.0053 |
| SCP2 | 1 | 13.1/19.3 | −32.1 | 0.0055 |
| MGC34646 | 8 | 14.9/9.8 | 51.4 | 0.0055 |
| EIF2AK2 | 2 | 12.1/8.0 | 52.1 | 0.0055 |
*
Adjusted for age, sex, Tanner stage, daily kilocalorie intake, and physical activity. Mean values were back-transformed to the original units.