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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: J Trauma Acute Care Surg. 2013 Jun;74(6):1454–1461. doi: 10.1097/TA.0b013e3182905ed2

Figure 2. TLR4-dependent post-traumatic lymphocyte dysfunction.

Figure 2

Splenocyte function at 48h after pseudofracture (PF) or in unmanipulated controls after concanavalin A (2.5μg/mL) stimulation: proliferation measured in counts per minute (cpm) of tritiated thymidine uptake (A), IFN- release (B) and IL-2 release (C). TLR4−/− mice compared to background C57BL/6 (WT B6) strain. TLR4-mutant mice (C3H/HeJ) compared to background strain C3H/HeOuJ (WT C3H). Data presented as percent change from baseline control. Data shown as mean±SEM; * = p < 0.05 vs. respective control; n=4–10 mice/group; representative of 2 independent experiments.