Table 6.
Differences in DNA methylation by car versus public transportation (PT) commute modes. New York, 2009-2010
| Car | PT | ||
|---|---|---|---|
| LINE-1 methylation, n | 72 | 93 | |
|
| |||
| Difference1 (95% CI) | |||
| %, Mean (SD) | 78.0 (2.1) | 78.3 (2.0) | 0.2 (-0.5, 1.0) |
| Median (IQR) | 78.4 (77.2 - 79.6) | 78.3 (77.3 – 79.3) | |
| Adjusted means | 78.1 | 78.2 | |
| Quartiles (%) | n (%) | n (%) | OR (95%CI) |
| Q1 (<77.2) | 18 (25.0) | 21 (22.6) | Ref. |
| Q2 (77.2, 78.2) | 17 (23.6) | 25 (26.9) | 0.6 (0.2, 1.7) |
| Q3 (78.3, 79.4) | 15 (20.8) | 25 (26.9) | 0.6 (0.2, 1.6) |
| Q4 (≥79.5) | 22 (30.6) | 22 (23.7) | 1.1 (0.4, 2.8) |
| IL-6 promoter methylation, N | 72 | 85 | Difference1 (95% CI) |
| %, Mean (SD) | 56.1 (11.8) | 58.0 (12.1) | 1.7 (-2.4, 5.8) |
| Median (IQR) | 56.0 (47.6-63.5) | 55.6 (50.9-66.1) | |
| Adjusted means | 55.6 | 58.4 | |
| Quartiles (%) | n (%) | n(%) | OR (95%CI) |
| Q1 (<49.8) | 21 (29.2) | 18 (21.2) | Ref. |
| Q2 (49.8, 55.8) | 14 (19.4) | 25 (29.4) | 0.4 (0.1, 1.0) |
| Q3 (55.9, 64.5) | 20 (27.8) | 19 (22.4) | 0.7 (0.2, 1.8) |
| Q4 (≥64.6) | 17 (23.6) | 23 (27.1) | 0.5 (0.2, 1.3) |
CI=Confidence Interval, IQR=Interquartile Range, OR= Odds Ratio
1
Linear regression and logistic regression models were adjusted for age, gender, race/ethnicity and BMI.