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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2012 Nov 1;1835(1):100–109. doi: 10.1016/j.bbcan.2012.10.003

Figure 2.

Figure 2

Intracellular S100A9 activity: S100A8/A9 binds to cell receptors initiating signal transduction through NFκB pathways promoting increased S100A9 transcription. Ca2+-S100A9 complexes with microtubules increasing cell motility. In addition, Ca2+-S100A9 increases the oxidative potential of cells by migrating to the NADPH complex via PKC dependent mechanisms and activating reactive oxygen species pathways. S100A9 is then released into the extra-cellular space.