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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2012 Nov 1;1835(1):100–109. doi: 10.1016/j.bbcan.2012.10.003

Figure 3.

Figure 3

Extra-cellular S100A9 activity A) S100A8/A9 sequesters zinc inhibiting the extracellular matrix degradation capacity of MMPs

B) S100A8/A9 or S100A9 serves to transport arachidonic acid (AA). Calcium binding to Apo-S100A9 (i) forms Ca2+-S100A9 (ii). The Ca2+-S100A9 (ii) protein binds to arachidonic acid forming the Ca2+-S100A9 –AA complex (iii). Zinc binding to Ca2+-S100A9 (ii) forms the Zn2+Ca2+-S100A9 complex (iv) and can no longer bind arachidonic acid.

C) S100A9 or S100A8/A9 binds to cell surface receptors initiating signal transduction cascades.