Table 1.

Exclusion criteria specific to the MsFLASH 3 by 2 factorial intervention trial

Criterion	Intervention Arm	Rationale
Body mass index >37	Exercise	Rapid progression of exercise prescription not appropriate for heavier women
Severe uncorrected hearing or vision problems.	Yoga	Need to hear and see yoga instructor
Current, regular use (≥3 times/week) of anti-coagulants	Omega-3	Potential omega-3 supplement interaction
Physical limitations, such as severely limited mobility, severe, recent or chronic back problems, and other musculoskeletal problems that limit the ability to walk on a treadmill or ride a stationary bicycle.	Exercise, yoga	Safety considerations and ensure ability to participate in yoga or exercise interventions, as designed
Presence of any absolute contraindications to exercise testing and training, as defined by the American College of Sports Medicinea	Exercise	Safety considerations
Practiced or attended yoga, tai chi, qi gong, or meditation more than one time per week on average in prior 3 months	Yoga	Maximize potential effect of yoga intervention
Participate in aerobic exercise more than 30 minutes a day on 3 or more days per week in prior 3 months	Exercise	Maximize potential effect of exercise intervention
Inability to achieve 85% of heart rate reserve (HRR) on graded exercise treadmill test.	Exercise	Provide standard measure of fitness and ensure ability to comply with exercise prescription
Allergy or sensitivity to fish	Omega-3	Contents of omega-3 supplement
Severe allergy to soy	Omega-3	Contents of omega-3 supplement
Currently eating 4 or more servings of fish per week.	Omega-3	Maximize potential effect of omega-3
Currently taking an omega-3 fish oil supplement and unwilling to stop	Omega-3	Maximize potential effect of omega-3

^aabsolute contraindications include resting ECG evidence of significant ischemia, unstable angina, and uncntrolled cardiac dysrhythmias; for complete list of absolute and relative contraindications, see Reference #24