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. Author manuscript; available in PMC: 2013 Jun 3.
Published in final edited form as: Curr Cancer Drug Targets. 2011 Jul;11(6):734–751. doi: 10.2174/156800911796191024

Figure 2.

Figure 2

Hierarchical development of mature peripheral blood cells and MDSC through differentiation of hematopoietic stem cells (HSC) in mice. Differentiation of HSC is considered normal until the Granulocyte/Monocyte Precursor (GMP) stage. GMPs fail to differentiate into mature PMN and monocytes in a tumor-bearing host. Instead, GMPs give rise to MDSC that bear markers of both PMN and monocytes, but do not express markers of fully-matured cells. Please note that this diagram is meant primarily to illustrate the origin and main phenotypic markers of MDSC rather than depict in great detail the various differentiation pathways.