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. Author manuscript; available in PMC: 2013 Jun 3.
Published in final edited form as: Sci Signal. 2012 Jun 12;5(228):ra43. doi: 10.1126/scisignal.2002437

Fig. 4. Enhancing netrin-mediated axon attraction by a lin-4 microRNA mutation.

Fig. 4

(A) Specific rescue of AVM axon guidance defects in slt-1 mutants by a loss-of-function lin-4 microRNA mutation. Anterior is to left, dorsal up. Scale bar, 20 μm. (B) Mutation in lin-4 microRNA specifically suppressed AVM axon ventral guidance defects in slt-1 (slit) and eva-1 but not unc-6 (netrin) and unc-40 (DCC) mutants. Error bars represent standard error of the proportion. Asterisks indicate that comparisons between slt-1 and lin-4; slt-1 and between eva-1 and lin-4; eva-1 are significantly different at P < 0.01 by Z-test for two proportions. (C) Cell-autonomous rescue of lin-4 mutant phenotypes in AVM axon guidance by a mec-4::lin-4 transgene. unc-54 and ajm-1 promoters were used to drive lin-4 expression in body wall muscles and hypodermal cells, respectively. Asterisks indicate that comparison is significantly different between lin-4; slt-1 with and without mec-4::lin-4 transgene at P < 0.01 by Z-test for two proportions.