Fig. 8. lin-14 functions through unc-40, madd-2, unc-34 and ced-10 to promote netrin-mediated AVM axon ventral guidance.
LIN-14 requires UNC-40, MADD-2, UNC-34 and CED-10 to stimulate netrin signaling. AVM was visualized with zdIs5[mec-4::gfp]. Asterisks indicate data significantly different from Ex[lin-14](-) controls (P < 0.001 by Z-test for two proportions).