. Author manuscript; available in PMC: 2014 Apr 1.

Published in final edited form as: Osteoarthritis Cartilage. 2013 Jan 23;21(4):634–641. doi: 10.1016/j.joca.2013.01.007

Table I.

Growth metrics and biochemical content of 4 weeks neocartilage constructs^*

Groups	Diameter (mm) (P = 0.4645)	Thickness (mm) (P = 0.2384)	Wet weight (mg) (P = 0.4566)	Water content (%) (P = 0.7472)	Cell number (millions) (P = 0.2669)
Groups	Control	5.21 ± 0.22	1.53 ± 0.11	29.87 ± 4.93	88.75 ± 13.23	3.01 ± 2.86
1st & 3rd weeks	5.17 ± 0.33	1.35 ± 0.25	29.65 ± 8.80	90.50 ± 12.11	4.03 ± 3.26
3rd & 4th weeks	5.11 ± 0.23	1.40 ± 0.22	26.45 ± 2.06	87.46 ± 7.93	4.24 ± 5.22
4th week	5.09 ± 0.33	1.48 ± 0.42	28.30 ± 7.42	87.81 ± 9.52	4.46 ± 4.39
Continuous	5.20 ± 0.24	1.45 ± 0.35	28.09 ± 10.95	88.19 ± 5.43	2.64 ± 2.22

The effects of hypoxia as a function of application time during the self-assembly of AC (control, 1st & 3rd weeks, 3rd & 4th weeks, 4th week, and continuous hypoxia groups) were examined on gross morphology (diameter, thickness, and WW) and biochemical properties (water content and cell number) after 4 weeks of culture. Values are mean ± 95% CI. No significant differences were detected among controls and hypoxia-treated groups. See Results section for details. Col = collagen.