Table 1.
Comparison of transsulfuration metabolites in cerebellum between control and TCE-treated mice.
| Glutathione and Cysteine Redox Status in cerebellum (nmol/mg/protein) | 0 mg/ml TCE | 0.01 mg/ml TCE | 0.1 mg/ml TCE |
|---|---|---|---|
| GSH | 22.22 ± 1.53 | 19.58 ± 0.87* | 17.92 ± 1.21** |
| GSSG | 0.27 ± 0.05 | 0.27 ± 0.03 | 0.29 ± 0.04 |
| GSH/GSSG ratio | 86.36 ± 18.46 | 71.76 ± 7.11 | 63.14 ± 7.11* |
| Oxidized GSH (%) | 2.33 ± 0.50 | 2.73 ± 0.27 | 3.09 ± 0.39* |
| Cysteine | 3.20 ± 0.44 | 2.51 ± 0.54 | 2.39 ± 0.76 |
| Cystine | 12.52 ± 1.23 | 14.38 ± 1.87 | 14.64 ± 0.79* |
| Cysteine/Cystine ratio | 0.26 ± 0.03 | 0.18 ± 0.05* | 0.16 ± 0.04* |
Data is presented as mean ± SD.
p≤0.05 is statistically significant
p<0.001.